Multicentric carpotarsal osteolysis syndrome (MCTO) is a rare autosomal dominant condition.

In some cases, there may also be craniofacial abnormalities including[citation needed] Histology of renal biopsies show glomerulosclerosis and severe tubulointerstitial fibrosis.

[3] This gene encodes a basic leucine zipper (bZIP) transcription factor.

[citation needed] The diagnosis may be suspected on the basis of the constellation of clinical features.

[4] The condition should be differentially diagnosed from juvenile rheumatoid arthritis and other genetic skeletal dysplasias as Multicentric Osteolysis, Nodulosis, and Arthropathy.