Munyonyo is bordered by Lake Victoria to the south, Bulingugwe Island to the southeast, Ggaba to the east, Salaama to the northeast, Buziga to the north, Makindye to the northwest, and Lubowa to the west.

Munyonyo is approximately 13 kilometres (8.1 mi), by road, southeast of Kampala's central business district.

[2] Munyonyo is one of the most upscale residential neighborhoods in the city of Kampala.

Catholic saints Andrew Kaggwa and Denis Ssebuggwawo Wasswa and Anglican Mukasa Musa were murdered on 25 and 26 May 1886 by King Mwanga II of Buganda.

On the same day in Munyonyo, four catechumens: Kizito, Gyaviira Musoke, Mbaga Tuzinde,[3] and Mugagga Lubowa were secretly baptized by Charles Lwanga, at that time the leader of Uganda's Christian community.