Murphy is a town in the General López Department in Santa Fe Province, Argentina.

It is named after an Irishman, John James Murphy, from Haysland, near Kilrane, County Wexford, close to Rosslare Harbour.

Born in 1822 into a Catholic family, Murphy was an unmarried son of middle-class tenant farmers, who decided to emigrate to better his prospects.

He expanded his holdings and later acquired huge tracts of land in the vicinity of Rojas, Buenos Aires and later in Santa Fe Province.

In 1911, the expansion of the railway system led to the compulsory purchase of land near Rosario, held by Murphy's heirs.