Nearby localities include Tell Qarah and Fafin to the north, Ratyan to the northwest, Huraytan to the southwest, the Bustan al-Basha and Sheikh Maqsoud neighborhoods of Aleppo to the south and Kafr Saghir to the southeast.

[2] In 1103 the Crusaders led by Bohemond I of Antioch and Joscelin of Courtenay captured al-Muslimiyah and exacted a large tribute from its Muslim inhabitants.

The sum was used to repay the Crusaders that lent money to Baldwin I of Jerusalem who paid the ransom for Bohemond's earlier release from Muslim imprisonment.

[6] On 29 October 1918, towards the end of World War I, the British and Sharifian Arab armies captured the railroad junction at al-Muslimiyah from the Ottomans, gaining control over the rail link to Mesopotamia.

The Syrian Police and Public Security Directorate reported that the mine was one of 30 that was swept to the area from the border with Turkey as a result of flood waters.