Created by means of a May 1837 Royal Order, the provincial museum was opened on 19 November 1838.

It moved to different premises, including the Palace of El Infantado, the former convent of La Concepción, back to La Piedad and the Palace of the Provincial Deputation.

[4] Following decades of discontinued existence, it was opened again at the Palacio del Infantado on 11 July 1973.

[5] Its management (not the ownership, retained by the Spanish State) was transferred to the Regional Government of Castile-La Mancha by means of a 1984 agreement.

[2] The museum displays items from the province of Guadalajara distributed in sections of Fine Arts, Archaeology and Ethnography.