The first collections obtained by the museum were donated by Arturo Taracena and David Vela.

In November 1964, the museum obtained a replica of the first printing press used in Guatemala, the plans were provided by UNE.

[1] The museum is divided into four exhibition rooms, which offer information about the history of printing during colonial times.

Also the museum contains a copy of a book that was printed in 1753 called "Arte de la lengua metropolitana del reino cakchiquel o guatemálico" by Ildefonso Joseph Flores, the printing was made by Sebastián Arévalo.

[3] The museum has a copy of a book by Fray Matías de Córdova [es].