It most notably takes place in a post-apocalyptic world where radiation has caused the human race to mutate and the dead to rise from the grave.

The instruction manual states that the exact causes of the upheaval have been lost or corrupted, due to (among many things) the chaos of an alien invasion, spin control, a sloppy filing system set up by a temp, and what appears to be barbecue sauce.

Landmines, fire pits, and other hazards (such as areas being open to empty space) litter the field, which can be made of rock, ice, or even toxic waste or rubber.

Teams have special Nasty Audibles, which are dirty, violent tricks such as exploding balls, invisibility, electric shocks, jet packs, or tackling the other quarterback with the intent to kill.

However, despite all of the death and destruction, the competition aspect is still high, and requires much strategy, especially compared to games like NFL Blitz.

In the Xbox 360 version of the video game Madden NFL 09, there is an achievement worth 50 gamerscore titled "Midway Monster".

A spiritual successor called Mutant Football League has been developed by Digital Dreams Entertainment for the PC, Xbox One, PS4, and mobile platforms.

This has been headed up by Michael Mendheim, the original creator and lead designer of the Mutant League series.