N-Methyltryptamine (NMT), also known as monomethyltryptamine, is a chemical compound of the tryptamine family and a naturally occurring compound found in the human body and certain plants.

[3] NMT is an alkaloid derived from L-tryptophan that has been found in the bark, shoots and leaves of several plant genera, including Virola, Acacia, Mimosa, and Desmanthus—often together with the related compounds N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT).

[6] Orally administered NMT appears to produce no psychoactive effects, likely as a result of extensive first-pass metabolism.

[6][8] NMT is known to act as a potent serotonin 5-HT2A receptor full agonist (EC50Tooltip half-maximal effective concentration = 50.7 nM; EmaxTooltip maximal efficacy = 96%).

[5] In the United States NMT is considered a schedule 1 controlled substance as an positional isomer of Alpha-methyltryptamine (AMT) [9]