[5][6][7] This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF) -like repeats.

The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation.

A similar protein in rodents is involved in craniosynostosis.

An alternative splice variant has been described but its full-length sequence has not been determined.

[6] Recent study by UCLA researchers shows that administering the protein NELL-1 intravenously stimulates significant bone formation through the regenerative ability of stem cells.