Members of this type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types.

Notch family members play a role in a variety of developmental processes by controlling cell fate decisions.

In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development.

This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer.

This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.