Its location is approximately 65 kilometres (40 mi), by road, northwest of Mulago National Referral Hospital.

[5] During the National Resistance Movement War in the early 1980s, the hospital served as a major health facility for the NRA guerrillas.

[5] In 2013, the government of Uganda borrowed money from the World Bank to construct and renovate certain hospitals, including Nakaseke General Hospital.

Build a kitchen and dining room for patients' families 10.

Build ventilated improved pit latrines for patient families and outpatients and 11.