A frequent collaborator of filmmaker John Carpenter, she portrayed Annie Brackett in Halloween (1978) and also appeared in his films Assault on Precinct 13 (1976) and The Fog (1980).
Before starring in Halloween, she played Julie in the 1976 thriller, Assault on Precinct 13, also directed by Carpenter.
In 1980, Kyes played the role of Sandy Fadel in Carpenter's hit horror film, The Fog, in which she appeared with her Halloween co-star Jamie Lee Curtis, her Assault on Precinct 13 co-star Darwin Joston, and Charles Cyphers, who appeared with Kyes in both Halloween and Assault on Precinct 13.
Kyes had a small role in Halloween III: Season of the Witch (1982) as the ex-wife of the lead character, played by Tom Atkins.
After retiring from acting, she worked as a sculptor in the Los Angeles area[1] along with teaching theatre courses at Cal Poly Pomona.