Michaela "Mikmik" Dimaano is a bright, wise cracking 9-year-old girl living happily with her mother Ella and her adoptive grandmother Ester in a quiet province.

Everything changes when Ella is diagnosed with late onset leukemia, the same time Mikmik discovers her true relations to Divina Salvador, a wealthy businesswoman.

In order to pay for her mother's medication, Mikmik, with the help of Ester, visits Divina but is rejected, as Ella is blamed for her step-brother Eric's death.

Mikmik immediately finds refuge and comfort in Benjie and Ruth's son Joseph, but has to face the spite and cruelties of her cold step-grandmother Divina, her wicked step-aunt Katrina, and her older step-cousin Amber.

When a mysterious man from the past named Michael Villaluna resurfaces and creates a paternal connection with Mikmik, things escalate to greater heights.