His career in entertainment started in 2005[2] He first starred in an indie film Matthew, Mark, Luke and John until GMA Network discovered his potential in acting.
He got a cameo role in Tope Lee's Quija a horror movie produced by GMA Films and released in 2007, he was also cast as David in Green Paradise co-star with Cristine Reyes.
In 2008, Serrano had as a recurring role of Babangon Ako't Dudurugin Kita, a remake of a Sharon Cuneta movie, which aired on GMA Network.
On December 23, 2009, Serrano signed with ABS-CBN to star as a major recurring character in suspense drama Kung Tayo'y Magkakalayo which premiered on January 18, 2010.
In 2011 Serrano was supposed to pick up by GMA-7's new epic series Amaya but he turned down the project offer due to his ongoing commitment on ABS-CBN.