The river originates in Sandown (S20.425036˚, E28.180660˚), a small farming town located on the Zimbabwean central watershed 50 kilometres (31 mi) south west of Bulawayo and ends in the Makgadikgadi Pans (S20.348816˚, E26.240166˚) in Botswana.

Impressive sedimentation starts occurring about 65 kilometres (40 mi) along the river course marking the beginning of a 90-kilometre (56 mi) stretch in Zimbabwe where the river passes through communal farming areas.

Within the country of Botswana the Nata River is a source of water to the ephemeral wetlands of the Makgadikgadi Pans, where a number of species of limited distribution thrive.

[1] Specifically the Nata River discharges to Sua Pan, draining parts of eastern Botswana and southwestern Zimbabwe.

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