Natalia is a city in Medina County, Texas, United States.

Natalia is part of the San Antonio Metropolitan Statistical Area.

Natalia is located approximately 30 mi (48 km) southwest of Downtown San Antonio in Medina County.

The climate in this area is characterized by hot, humid summers and generally mild to cool winters.

19.3% of all households were made up of individuals, and 8.6% had someone living alone who was 65 years of age or older.