He met his future wife, Sarah Goff, during the 1866 cholera epidemic in Wapping, where he first determined a need for a children's hospital in the East End of London.
The hospital started in 1868 in a warehouse in Ratcliffe, and moved after his death to Glamis Road, Shadwell.
It was described in some detail by Charles Dickens in two pieces called 'A Small Star in the East' and 'On An Amateur Beat' published in The Uncommercial Traveller.
The newly merged institution was called Queen Elizabeth Hospital for Children until its closure in 1963.
Created in the early 21st century, it is a small business park, mostly occupied by electrical and building trades.