Formerly known as Sherwood and Greenlee, the community is located along the James River and Virginia State Route 130, 3.2 miles (5.1 km) west of Glasgow.

Natural Bridge Station is made up mostly of the southeastern corner of Rockbridge County encompassing all of the community of Arnolds Valley (named for the area's first settler, Stephen Arnold) and partially covering several other communities, with its southeastern border running along the Blue Ridge Parkway.

Local law enforcement for Natural Bridge Station is administered by the Rockbridge County Sheriff's Department located in Lexington.

Some areas of Natural Bridge Station along the Blue Ridge Parkway are patrolled by the National Park Service.

Natural Bridge Elementary School is located within the "downtown" zone of the community and serves most of southern Rockbridge County.