The Navajo Tribal Council appointed Guy Gorman, Yazzie Begay, Chester Yellowhair, Carl Todacheene, Wilson Skeet, Howard Gorman, Allen Yazzie, and Dillon Platero to be the first to serve on the college's Board of Regents.

[8] After a Board-commissioned survey of possible sites for the college, the Tsaile–Wheatfields area was recommended because it had plenty of water available and has scenic forests and lakes.

[14] In October 1973, following construction delays, students began taking classes at the college's permanent campus in Tsaile.

[15] Most campus buildings were built in octagonal shapes, similar to the eight-sided traditional Navajo hogan.

On May 21, 2011, the women's archery team made history by winning the United States college national championship in compound bow.

[19] This is believed to be the first time a tribal college team has won a top-tier intercollegiate national championship event in any sport.

In 2019, the Chicago-based Higher Learning Commission (HLC) approved Diné College’s four-year institution status and two additional emphasis options within the BA of Fine Arts degree: silversmithing and weaving.

The main campus of Diné College is in Tsaile, a census-designated place in unincorporated Apache County, Arizona.

The college is directed by an eight-member Board of Regents confirmed by the Government Services committee of the Navajo Nation Council.