Nazlat 'Isa (Arabic: نزلة عيسى) is a Palestinian village in the Tulkarm Governorate in the western West Bank, located 17 kilometres (11 mi) North of Tulkarm.

"[4] In the 1922 census of Palestine conducted by the British Mandate authorities, Nazlet Esa had a population of 203 Muslims,[5] increasing in the 1931 census to 261 Muslims, living in 62 houses.

[10] In the wake of the 1948 Arab–Israeli War, and after the 1949 Armistice Agreements, Nazlat 'Isa came under Jordanian rule.

In 2003, during the Second Intifada, over 60 shops were destroyed by Israeli civil administration bulldozers.

The Israeli civil administration claimed that the shops were demolished because they were built without a permit.