According to the Palestinian Central Bureau of Statistics, Saffarin had a population of about 1,037 inhabitants in mid-year 2006 and 754 by 2017.

The inhabitants paid a fixed tax rate of 33.3% on agricultural products, including wheat, barley, summer crops, olive trees, goats and beehives, in addition to occasional revenues and a press for olive oil or grape syrup, and a fixed tax for people of Nablus area; a total of 9,167 akçe.

[12] In 1870/1871 (1288 AH), an Ottoman census listed the village in the nahiya (sub-district) of Wadi al-Sha'ir.

[13] In 1882 the PEF's Survey of Western Palestine (SWP) described Sefarin as: "a small village on a knoll, upon a ridge, supplied by cisterns, with a few olive trees.

"[14] Around the turn of the 20th century, Saffarin was one of the villages in which the Hannun family owned extensive estates.