The railway was an important link during World War I as the Ottoman Empire, Bulgaria, and Austria-Hungary were all Central Allies.

The sections from Alexandroupoli to Svilengrad, except for a short section of about 10 kilometres (6.2 mi)[5] in Turkey serving Edirne Karaagaç station and for 3 kilometres (1.9 mi) between the Greek border and Svilengrad station in Bulgaria[6] come under the control of the French-Hellenic Railway Company (CFFH), a subsidiary of the CO, when the CFFH was incorporated in July 1929.

In Greece, a line was opened to allow trains from Pythio to Bulgaria to stay on Greek territory and avoid Edirne.

The then SEK designed and constructed a 9 km (5.6 mi) direct connection between Nea Vyssa and Marasia within the Greek borders, thus avoiding Turkish territory and bypassing Karaağaç.

The project for the Pythian-Ormenio section envisions upgrading the existing line infrastructure and trackbed, doubling of the track as well as the installation of electrification signalling (ETCS Level 1) along the entire stretch, with the aim of improving freight transport with Bulgaria and Turkey.

At platform level, there is no outside seating, Dot-matrix display departure and arrival screens, nor timetable poster boards for passenger information.As a result, the station is currently an unstaffed halt.