It has a southern terminus west of Osceola at an intersection with Nebraska Highway 92.

Its northern terminus is at an intersection with Nebraska Highway 14 southeast of Albion.

It goes north through farmland, crosses the Platte River and meets U.S. Highway 30 at Silver Creek.

It runs northwesterly and crosses over the Loup River shortly before meeting Nebraska Highway 22.

It goes west out of St. Edward and at an intersection with Nebraska Highway 56, turns northwest again.