N-88 starts at the Nebraska–Wyoming state line in Banner County, where WYO 151 ends, and travels northeast.

The road quickly bends east after less than one mile (1.6 km), and continues in a straight line.

The route continues to travel through farmland for 16 miles (26 km), where it enters Morrill County.

The road crosses over Pumpkin Creek four times, and enters the unincorporated community of Redington.

The road crosses over Pumpkin Creek for the fifth time, and enters into Bridgeport five miles (8.0 km) later.

[4] The route remained relatively the same as the state highway system was officially designated.