The player takes the role of Simon Bukner, a young American soldier recently recruited into the British Army.

In addition to German soldiers, Simon soon finds himself fighting supernatural forces, including vampires, demons, and zombies found in locations varying from the battlefields of World War I to secret laboratories and caverns.

The main setting is the Battle of the Somme, during which a rumor of a mysterious infection has appeared, which causes all people to turn into zombie-like state.

The soldier continues rambling due to battlefield stress about having German passwords and other intel, including some on patrol routes.

At the basement lab of the stronghold, the player discovers a mechanical walking tank created by the Vampires.

After getting rid of Zimmerman, Simon is chosen as the owner of the new Shadow Hand with Menthor inside - the spirit of an old Vampiric champion, bound within the glove.

After a long journey, Simon mounts an ancient dragon and makes his way to Hell itself, where he battles Mephisto's second-in-command, the fallen angel Azazel (who rides three-headed Cerberus).

The game has three endings, which are chosen based on the difficulty level: NecroVisioN is a first-person shooter which also has a close-combat system and an ability to use both arms with different weapons.

The gameplay is varied, and includes combo system, challenge mode, and storyline sections where player pilots a Vampire-made robotic exosuit and rides a dragon.

Martyn Clayden of IT Reviews had said that the game is a mix of H. P. Lovecraft and Medal of Honor set in World War I.

It features Jonas Zimmerman as the protagonist, and shows him fighting against demonic invaders during the war, slowly discovering the vampire tech.