Neisseria sigma-E sRNA (NSE sRNA) is a non-coding RNA found in the bacterial genus Neisseria, including the two pathogens N. meningitidis and N. gonorrhoeae.

The RNA was discovered in a screen for genes differentiated by high expression of the Sigma factor, sigma E.[1] Seven genes were predicted to be regulated by NSE sRNA, including fur, nadC and a putative TetR family transcriptional regulator, through base-pairing interactions with the 5' UTR.

The sRNA transcript is terminated by a rho independent terminator.

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