Since earning a starting position as a rookie, White became one of the league's top cornerbacks as part of a resurgent Bills defense,[1] having garnered two Pro Bowl selections and All-Pro honors.

[4] White committed to Louisiana State University (LSU) to play college football under head coach Les Miles.

[5] White stated that he originally committed to LSU as a wide receiver, but that he chose to remain a defensive back when he realized he was unlikely to see significant playing time on a roster that included future NFL stars Odell Beckham Jr. and Jarvis Landry.

[11][12] White was expected to be a late first-round choice in the 2016 NFL draft, but he instead chose to return to LSU for his senior season.

[15] He was able to raise his draft stock after practicing well and showing an ability to learn quickly while working with Cleveland Browns defensive backs coach DeWayne Walker for the Senior Bowl.

White also participated at LSU's Pro Day and opted to attempt to beat his combine times in the 40, 20, and 10-yard dash, but was unable to.

[29] In Week 4, he made four combined tackles, a pass deflection, and returned a fumble recovery for his first career touchdown during a 23–17 upset win over the Atlanta Falcons.

[30][31][32] On October 22, 2017, White tackled wide receiver Adam Humphries, forcing him to fumble the ball, and recovered it to set up the Bills' game-winning field goal during their 30–27 victory against the Tampa Bay Buccaneers.

[33] On November 26, 2017, White intercepted a pass from quarterback Alex Smith and returned it 63 yards with 1:28 left in the fourth quarter of the Bills' 16–10 victory at the Kansas City Chiefs.

Immediately after the play, Gronkowski jumped elbow-first onto White while he was still on the ground and drew a personal foul penalty.

Gronkowski was upset, claiming that White should have been flagged for a pass interference penalty, but nonetheless was suspended one game for the hit.

[35] White started all 16 games as a rookie in 2017 and recorded 69 combined tackles (53 solo), 18 pass deflections, and four interceptions.

On January 7, 2018, White started in his first career playoff game and recorded a tackle and a pass deflection during the Bills' 10–3 loss at the Jacksonville Jaguars in the AFC Wild Card Round.

[44] In week 9 against the Washington Redskins, White recorded his first career sack on rookie quarterback Dwayne Haskins in the 24–9 win.

[46] White recorded his second game of 2019 with two interceptions in week 15 against the Pittsburgh Steelers on Sunday Night Football, picking off quarterback Devlin Hodges twice.

[50] White finished with five combined tackles, including a forced fumble on Hopkins which was recovered by teammate Tremaine Edmunds, as the Bills lost 22–19 in overtime.

[56] In Week 15 against the Broncos, White forced a fumble on quarterback Drew Lock that was recovered by Hughes, who returned it for a 21 yard touchdown during the 48–19 win.

[65] White noted that the injury was the first time since middle school that he, a three-sport athlete in high school, had been sedentary, and briefly fell into depression; he eventually was coaxed out by his former LSU teammates, Bills teammates and reporter Michele Tafoya, a personal friend; he purposely chose to slow-walk his injury recovery in deference to the training staff's decisions.

The commercial became a sort of running gag for White, who notes the similarities between the goaltender and defensive back positions in that both serve as a last line of defense against scoring, and that there were no collegiate hockey teams in Louisiana (White had been a track and basketball star during football offseason in high school[6]).