She debuted in 2007 and actively appeared in a few television dramas and popular in the drama Setia Hujung Nyawa as Ersalina,[2] Bukan Kerana Aku Tak Cinta as Hannah Mastura dan Lafazkan Kalimah Cintamu as Tengku Aqilah.

At the age of 13, Nelydia Senrose began her acting career by playing the supporting role Melissa in TV3's primetime series Spa Q.

Her breakthrough as an actress came when she starred with Amar Asyraf in Setia Hujung Nyawa, a drama series based on the novel of the same title where she played Ersalina.

She was later cast as Ara in Cinta Tiada Ganti, a remake of 2003 Filipino telenovela, Sana'y Wala Nang Wakas.

[7] In July 2013, the Malaysian private, free-to-air television channel, TV3 appointed Senrose along with Adi Putra, Nora Danish, Fiza Sabjahan, Amar Asyraf, Neelofa, Tasha Shilla and Aiman Hakim Ridza as the ambassador for Anugerah Syawal 2013.