After a revamp of the Radio 1 daytime schedule from early 2004, Nemone replaced Scott Mills on the overnight show (4 am – 7 am) broadcasting to audiences in excess of 3 million.

She left Radio 1 in September 2005; JK and Joel (Monday-Thursday) and Fearne Cotton and Reggie Yates (Friday) took over her early morning slot.

The requirement to take the show to Media City in Salford meant Nemone passing on the opportunity of returning to Manchester; electing to stay in London where she had established her young family.

Designing her own show, she has been able to draw on her passion for electronic music, especially championing female DJs, producers and artists like Róisín Murphy, Anna Meredith, Blessed Madonna, Jayda G, Deena Abdelwahed, Maya Jane Coles, Ellen Allien, Sister Bliss, Francesca Lombardo, B Traits, Peggy Gou, Park Hye Jin, Mary Epworth, Laura.

[4] Nemone's signature musical taste is for quirky vocal samples and wonky beats, alongside funky edged deeper house and techno.

[6] She took Dusky and Luke Solomon to Bestival with her to play for her Electric Ladyland Love Show and Simian Mobile Disco joined her at Green Man Festival.

[citation needed] Nemone has also curated 6 Music Festival Lates gigs over the last decade sharing the decks with Daniel Avery, Rob Da Bank, Richy Ahmed, Hercules and Love Affair’s Andy Butler, Julio Bashmore, Nightwave, Rebecca Vasmant, Soulwax, Erol Alkan, Max Cooper, Breakwave, Norman Jay, DJ Yoda, Kelly Lee Owens.

Nemone participated with her daughter in the Bumps & Babies Mile in Battersea Park for Sport Relief 2010 along with Denise Van Outen, Carly Cole, Gail Emms, Natasha Kaplinsky and Kim Medcalf.

[10] She is also a proponent of the wellbeing effects of wild swimming, having swum herself outdoors in Capri, Menorca, Skopelos, the Oman fjords, West Wittering, and close to home in London.

She was singer and saxophonist in a funk band – other members being Tom Findlay (who went on to form Groove Armada),[11] Andy Spence (from New Young Pony Club), and Perrier Award-winning comedian Dan Antopolski.

She is a keen open water swimmer, having participated in swim treks in Capri, Menorca, the Greek Islands, the Oman fjords as well as the South East of the UK.