[13] Low renal blood flow activates the renin–angiotensin–aldosterone system (RAAS), causing fluid retention and mild hypertension.

[14] As the kidneys inflame, they begin to excrete needed protein from the affected individual's body into the urine stream.

The most serious complication of nephritis can occur if there is significant loss of the proteins that keep blood from clotting excessively.

[19] Worldwide, the highest rates[clarification needed] of nephritis are 50–55% for African or Asian descent followed by Hispanic at 43% and Caucasian at 17%.

[20] The average age of an individual diagnosed with kidney inflammation (in this case, lupus nephritis) is 28.4 years old.