Nephrolenellus is an extinct genus of trilobite, fossil marine arthropods, of relatively small size (sagittal length of cephalon rarely exceeds 11 mm).

[2] Nephrolenellus multinodus occurs in the late Lower Cambrian of California (Toyonian, Pyramid Shale Member, Carrara Formation, Inyo County, 35.8° N, 116.2° W).

[3] and of Nevada (Toyonian, Lincoln County; and C-Shale Member, Pioche Formation, Ruin Wash, Chief Range, 37.8° N, 114.6° W).

Although most of the body is rather flat, the frontal lobe (L4) of the central area of the cephalon (or glabella) is raised, but not bulbous, and does not overlap the border at the front in dorsal view.

Typically for Nephrolenellus the eyeridges are pointing backwards and significantly (45°) outwards (along the tangent between the base and termination).