[2] She first appeared in Lloyd's Register in 1816 with Innerarity, master, Hook & Co., owners, and trade London–Bengal,[4] suggesting that she had taken on British registry and was sailing to Bengal under a license from the EIC.

[3] On her one voyage for the EIC she left Portsmouth on 6 July 1827 under the command of Captain John Altham Cumberlege, Jr.,[1] bound for Bengal.

On her return voyage she passed Kedgeree on 14 February, reached Madras on 3 March and St Helena on 18 May, and arrived at the Downs on 12 July.

[7] On her first convict voyage, under the command of William Ferris and surgeon Joseph Steret, she departed Sheerness on 7 October 1837 and arrived in Hobart on 18 January 1838.

[9] Neptune sailed from Cork, Ireland, on 26 October 1843, still under the command of William Ferris, and with 308 bounty emigrants aboard.