Co-hosts include comedians Blaine Capatch and Dan Telfer, actors Ken Daly and Chris Tallman, and writer Sarah Guzzardo.

The podcast has alternated several co-hosts through the years, and stems from a real-life ongoing game that also included comedian Patton Oswalt.

Former co-hosts Gerry Duggan, Sark, and Steve Agee have left the show but returned as guests.

Though they have played the Tomb of Annihilation pre-made adventure for their Patreon supporters as bonus episodes, the majority of the podcast consists of stories created by the respective Dungeon Masters.

[4][better source needed] Guests on bonus episodes have included Paget Brewster, Jackie Kashian, Joe Manganiello, Matthew Mercer, Marisha Ray, and Paul F. Tompkins.