He was the son of Filippo Corsini and Maddalena Machiavelli.

A cleric of the Camera Apostolica under pope Innocent X, he became Tesoriere in 1660.

He was made a cardinal presbyter in the 14 January 1664 consistory and two months later given the titulus of Santi Nereo e Achilleo.

From 1672 to 1677 he was put in charge of the diocese of Arezzo as a personal titular of the archbishop.

His remains are buried in the Corsini Chapel in Santa Maria del Carmine.