Neshannock Creek is a 25.65 mi (41.28 km) long tributary to Shenango River that forms at the confluence of Cool Spring and Otter Creek in Mercer County and then flows south to Lawrence County, Pennsylvania.

This creek is known for its fly fishing at Volant, Pennsylvania.

[5] Neshannock is a Native American name purported to mean "double stream".

The creek then flows south to join the Shenango River at New Castle, Pennsylvania.

[2] Neshannock Creek drains 240.41 square miles (622.7 km2) of area, receives about 41.3 in/year of precipitation, has a wetness index of 466.95 and is about 41% forested.