[2] NCG7.1 also reports the system-level properties and the associated publications of each driver, as well as a list possible false positives.
NCG7.1 collects 591 well-known (canonical) and 2,756 candidate cancer drivers.
These lists derive from the manual curation of 313 original publications, including 3 sources of canonical drivers [3][4][5] and 310 cancer sequencing screens.
Recent technological advances have enabled detection of genomic instability also in healthy (non cancer) cells driving in situ formation of phenotypically normal clones.
An important component of the TME are immune cells, which may hamper or help tumour growth.