Neurofuran

Neurofurans are 22-carbon compounds formed nonenzymatically by free radical mediated peroxidation of docosahexaenoic acid (DHA), an ω-3 essential fatty acid.

The neurofurans are similar to the isofurans and are formed under similar conditions of oxidative stress, containing a substituted tetrahydrofuran ring.

Measurement of the neurofurans may ultimately prove useful in diagnosis, timing, and selection of dosages in the treatment and chemoprevention of neurodegenerative disease.

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Chemical structure of an example neurofuran derived from the fatty acid docosahexaenoic acid (DHA)