New Florence is a city in Montgomery County, Missouri, United States.

[7] New Florence is in central Montgomery County and lies at the junction of Interstate 70 and Missouri Route 19.

Highway 19 passes through the west side of the city and is accessible from Interstate 70 via Exit 175.

New Florence includes a branch of Stone Hill Winery, based in Hermann.

From here to the St. Louis suburbs is the geographic area known as the Missouri Rhineland, first established as a center of vineyards by German immigrants in the mid-19th century.

[1] The city sits along a slight ridge which drains north toward Elkhorn Creek, part of the Cuivre River watershed flowing east to the Mississippi River; and which drains west to Smith Branch, part of the Loutre River watershed flowing south to the Missouri.

The southwest corner of the city drains into Calhoun Hollow and Clear Creek, another tributary of the Loutre.