The road runs between Brookline and Nashua, passing through the town of Hollis in the middle.

The western terminus of NH 130 is at the junction with New Hampshire Route 13 in Brookline as Milford Street.

The eastern terminus of NH 130 is in Nashua at New Hampshire Route 101A (Amherst Street), at which point NH 130 is named Broad Street.

The entire route is in Hillsborough County.

This New Hampshire road-related article is a stub.