The highway runs through alternating stretches of open, lightly developed terrain and undeveloped woodlands, meeting Solvay Road (CR 238) as it descends into Tully Valley, a wide gully surrounding Onondaga Creek.

The route heads north along the eastern edge of the isolated valley, following the creek into the adjacent town of LaFayette.

[3] At this point, maintenance of the route shifts from the New York State Department of Transportation (NYSDOT) to the Onondaga Nation.

[4] Inside the Onondaga territory, the route initially serves only a handful of scattered homes separated by long stretches of dense forests.

After 2 miles (3.2 km), however, the road bends to the northeast and enters the town of Onondaga and the hamlet of Indian Village, the main population center of the reservation.