Its northern terminus is at a junction with NY 66 in the hamlet of Wynantskill, located within the town of North Greenbush.

Now known as Brookview Road, NY 150 turns northeastward through Schodack, becoming a two-lane rural street along the Moordener Kill.

[3] Continuing to the northeast, NY 150 reaches the hamlet of Brookview, crossing a junction with the eastern terminus of CR 8 (Western Road).

A residential road through Schodack, NY 150 passes south of Evergreen Cemetery, paralleling the Moodener Kill.

Progressing northeast through Schodack, the rural roadway begins winding northward, reaching the eastern terminus of NY 151 (Luther Road).

[3] NY 150 was assigned as part of the 1930 renumbering of state highways in New York to an alignment extending from Castleton-on-Hudson northeastward to Schodack Center.