Upon assuming an eastward route, the highway crosses over a series of Amtrak tracks, passing south of the Albany–Rensselaer rail station and entering a more residential area.

NY 151 turns slightly towards the northeast as it leaves the city of Rensselaer[4] and becomes maintained by the New York State Department of Transportation (NYSDOT) as it passes into the town of East Greenbush.

After 0.5 miles (0.8 km), the highway curves to the southeast, intersecting County Route 63 (CR 63) and changing street names to Red Mill Road in the process.

After resuming a southeastern path, the route loses its street name and terminates at NY 150 in Shivers Corners, a hamlet in the town of Schodack.

[4] NY 151 was assigned as part of the 1930 renumbering of state highways in New York to a routing similar to its current alignment.