The route was realigned slightly in the late 1960s following an expansion of the Greater Rochester International Airport's primary runway.

As it approached the Greater Rochester International Airport, the homes were gradually replaced by industrial factories and warehouses.

East of the runway, the route gradually curved to the northeast before ending south of the airport at a junction with NY 383 2 miles (3.2 km) southwest of the city of Rochester.

[5] The east–west highway connecting the hamlet of Chili Center to the western bank of the Genesee River by way of the community of Maplewood was originally known as Clifton Road.

[2][3] In the late 1960s, the then-Rochester–Monroe County Airport expanded its primary runway southward across a tract of land that included part of NY 252A's routing.

Under the terms of the act, it took effect 90 days after it was signed into law; thus, the maintenance swap officially took place on November 26, 2007.