The segment of Route 15 between Mumford and Scottsville became part of NY 253 in the 1930 renumbering of state highways in New York.

Taking on the name Scottsville–Mumford Road, NY 383 follows Oatka Creek east through open fields and passes through the small hamlet of Garbutt on its way to the village of Scottsville, where it becomes Caledonia Avenue.

Past this junction, the surroundings shift from village streets to housing tracts as the route exits Scottsville.

[citation needed] Within Chili, NY 383 parallels the path of the Genesee River, which Oatka Creek feeds into east of the village of Scottsville.

It continues along the riverbank as it proceeds northward, passing over Black Creek and crossing the West Shore Subdivision, a rail line owned by CSX Transportation.

[citation needed] At this point, maintenance of NY 383 shifts from the New York State Department of Transportation to the city of Rochester.

[4] Scottsville Road continues within the city for four blocks to a three-way junction with Genesee Street and Elmwood Avenue.

NY 383 continues north on Plymouth Avenue through densely populated sections of the city to Ford Street.

The route curves east to follow Ford for one block to Exchange Boulevard, where it turns back to the north toward downtown Rochester.

Past the bridge, the highway enters downtown, where it passes the City of Rochester Public Safety Building and the Blue Cross Arena before terminating at a junction with East Broad Street (NY 31).

[9] The portion of former legislative Route 15 from Mumford to Scottsville and the segment of pre-1921 legislative Route 15 on Main Street in Scottsville was designated as the westernmost portion of NY 253, a highway extending from Mumford to Henrietta, as part of the 1930 renumbering of state highways in New York.

[19][20] The route's former alignment on Plymouth Avenue was split into two segments in the late 1980s as part of a larger reconfiguration of Corn Hill's street layout.