Crossing north through the city center, the route passes Johnson Park and reaches the Elmwood neighborhood of Buffalo.

[3] Continuing north along Delaware Avenue, NY 384 crosses through Tonawanda as a four-lane commercial strip, passing the Bartender's Professional Training Institute.

Crossing into the Elmwood North section of Tonawanda, NY 384 leaves the cemetery and enters exit 1A of I-290 (the Youngmann Expressway).

After I-290, NY 384 continues north along Delaware Avenue through the Cardinal O'Hara section of the city, shrinking to two lanes in the residential neighborhood.

Crossing under active railroad tracks, the route changes monikers to Delaware Street and begins to enter the City of Tonawanda.

Near Webster Street, the route turns northwest, paralleling nearby railroad tracks into a junction with NY 265 (River Road).

Entering the city of Niagara Falls, the routes become known as Buffalo Avenue, paralleling the LaSalle into Griffon Park.

Remaining in the shadows the LaSalle, NY 384 crosses over Cayuga Creek and enters the city center of Niagara Falls.

Proceeding southeast and away from the LaSalle, the route continues through the eastern edges of the city, passing numerous residences along the two-lane roadway.

Around the junction with 79th Street, the route becomes more commercial in nature, making a large curve around the riverside into an interchange the terminus of the Niagara Scenic Parkway.

Running northeast along Buffalo Avenue, the route now begins to parallel the Niagara Scenic, entering the industrial section of the city near 53rd Street.

The NY 384 designation terminates at the junction with Rainbow Boulevard rather than continuing through Niagara Falls State Park onto the bridge to Ontario.

[7] NY 384 was assigned as part of the 1930 renumbering of state highways in New York to the primary riverside roadway between the cities of Buffalo and Niagara Falls.

While Route 30 ended at the Niagara Falls city line, NY 384 continued west along Buffalo Avenue into downtown.

[9][11] NY 384 was rerouted slightly by 1948 to follow Delaware Avenue through Tonawanda and across the Erie Canal to the modern junction of Main and Webster Streets, where it rejoined its previous alignment.

[16][19] In December 2005, construction began on a project to convert the Rainbow Boulevard one-way couplet into dual-direction streets.