[5][6][7] As a redshirt sophomore, Petit-Frere was named second-team All-Big Ten after starting all seven of Ohio State's games in the team's COVID-19-shortened 2020 season.

[9] Nicholas Petit-Frere was invited to the NFL Scouting Combine along with other top offensive linemen after an impressive career at Ohio State.

He was ranked as the sixth-best offensive tackle prospect, behind Evan Neal, Ikem Ekwonu, Charles Cross, Bernhard Raimann, and Trevor Penning.

[16][17] Overall, Petit-Frere played in 16 games (16 starts) in his rookie season and appeared in 97% of the offensive snaps that year, allowing five sacks and committing eight penalties.

[20][21] Petit-Frere returned from injury to begin the 2024 season at starting right tackle, but was moved to third string behind Leroy Watson and Jaelyn Duncan on Week 6 after allowing too many pressures.