Loftin attended W. B. Ray High School in Corpus Christi, Texas, where he played baseball.

[4] In 2018, Loftin's freshman year at Baylor, he appeared in 55 games (making 53 starts), batting .306 with six home runs and 36 RBIs, earning Freshman All-American honors alongside being named to the Big 12 Conference All-Second Team and All-Freshman Team.

The Kansas City Royals selected Loftin with the 32nd overall pick in the 2020 Major League Baseball draft.

[20] Loftin was assigned to the Quad Cities River Bandits of the High-A Central for the 2021 season, slashing .289/.373/.463 with ten home runs and 57 RBIs over ninety games.

[27] On May 31, 2024, Loftin pitched a scoreless ninth inning in relief during a blowout against the San Diego Padres.