[1] Serino was born in Thunder Bay, Ontario and attended Superior Collegiate and Vocational Institute.
[2] Serino won the Canadian Screen Award for Best Supporting Actor at the 4th Canadian Screen Awards in 2016, for his role in the film Sleeping Giant.
[3] He appears in the film as Nate, one of three teenagers spending the summer together near Thunder Bay, Ontario; his character's cousin Riley is played by Serino's real-life cousin Reece Moffett.
[5] Following Sleeping Giant, Serino was cast as a recurring character in the crime drama television series Cardinal.
[6] In 2019 he appeared in the film Restless River (La rivière sans repos).