On the first day of her mountain guide course in 1984, the instructor called for a "Mr. Nicole Niquille", not expecting a woman to be participating in the course.

[8] In 1985, she made an expedition to K2, where she lived for two months at base camp, and fell in love with the Himalayas and the people.

[2] She cut her trip to the Himalayas short to return to Switzerland to complete her certification to become a mountain guide.

[13][14] Her certification process required her to complete every exercise as the men on the course, where she estimates she was tested twice as hard.

[2][16] In Switzerland, her graduation was widely reported, as women only received the right to vote in 1971 and were excluded from the Swiss Alpine Club until 1980.

[5] In 2022, Niquille summitted the Breithorn in Zermatt (4,163 m) in a specially designed sled, escorted by a rope team of 16 women.

[12][24] In October of that year, she was honored with a Lifetime Achievement Award by the Swiss Paraplegic Foundation for being a role model for disabled people in Switzerland.