Tablets are available only by prescription and contain the active ingredients nicotinamide, zinc, copper, and folic acid.
[citation needed] Results from a well-controlled clinical trial in Caucasian and Japanese women have shown that 4-6 weeks of application of 2% nicotinamide moisturiser to the face decreases sebum production with significant differences in facial shine and oiliness.
Nicotinamide gel is marketed as an over-the-counter treatment for acne in Canada, Australia, NZ, UK, USA and Ireland.
[3] Nicomide is distributed by Sirius Laboratories Inc., a wholly owned subsidiary of DUSA Pharmaceuticals.
DUSA ceased distributing Nicomide in June 2008 and set up an agreement with River's Edge Pharmaceuticals to allow them to distribute the product under DSHEA[clarification needed] in August 2008 but the deal appears to have fallen through.